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Title: A magnetic soft endoscopic capsule-inflated intragastric balloon for weight management
Authors: Do, Thanh Nho
Ho, Khek Yu
Phee, Soo Jay
Keywords: DRNTU::Engineering::Mechanical engineering
Adaptive Clinical Trial
Weight Management
Issue Date: 2016
Source: Do, T. N., Ho, K. Y., & Phee, S. J. (2016). A magnetic soft endoscopic capsule-inflated intragastric balloon for weight management. Scientific Reports, 6, 39486-. doi:10.1038/srep39486
Series/Report no.: Scientific Reports
Abstract: Overweight and obesity have been identified as a cause of high risk diseases like diabetes and cancer. Although conventional Intragastric Balloons (IGBs) have become an efficient and less invasive method for overweight and obesity treatment, the use of conventional tools such as catheter or endoscope to insert and remove the IGBs from the patient’s body causes nausea, vomiting, discomfort, and even gastric mucous damage. To eliminate these drawbacks, we develop a novel magnetic soft capsule device with gas-filled balloon inflation. The balloon is made from a thin and biocompatible material that can be inflated to a desired volume using biocompatible effervescent chemicals. In addition, both the outer balloon and inner capsule are designed to be soft and chemical resistance. The soft capsule shell is fabricated using scaffold-solvent approach while the outer balloon utilizes a novel fabrication approach for 3D spherical structure. A prototype of the proposed capsule and balloon is given. Experiments are successfully carried out in stimulated gastric environment and fresh porcine stomach to validate the effectiveness and reliability of the proposed approach.
DOI: 10.1038/srep39486
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2016 The Authors (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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