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Title: Transformation of Cortex-wide Emergent Properties during Motor Learning
Authors: Makino, Hiroshi
Ren, Chi
Liu, Haixin
Kim, An Na
Kondapaneni, Neehar
Liu, Xin
Kuzum, Duygu
Komiyama, Takaki
Keywords: Motor learning
Wide-field calcium imaging
Issue Date: 2017
Source: Makino, H., Ren, C., Liu, H., Kim, A. N., Kondapaneni, N., Liu, X., et al. (2017). Transformation of Cortex-wide Emergent Properties during Motor Learning. Neuron, 94(4), 880-890.e8.
Series/Report no.: Neuron
Abstract: Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements.
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.04.015
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Elsevier Inc.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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