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Title: Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment
Authors: Mogal, Vishal T.
Yin, Chaw Su
O’Rorke, Richard
Boujday, Souhir
Méthivier, Christophe
Venkatraman, Subbu S.
Steele, Terry W. J.
Keywords: Radicals
Issue Date: 2014
Source: Mogal, V. T., Yin, C. S., O’Rorke, R., Boujday, S., Méthivier, C., Venkatraman, S. S., et al. (2014). Tuning Model Drug Release and Soft-Tissue Bioadhesion of Polyester Films by Plasma Post-Treatment. ACS Applied Materials & Interfaces, 6(8), 5749-5758.
Series/Report no.: ACS Applied Materials & Interfaces
Abstract: Plasma treatments are investigated as a post-production method of tuning drug release and bioadhesion of poly(lactic-co-glycolic acid) (PLGA) thin films. PLGA films were treated under varying conditions by controlling gas flow rate, composition, treatment time, and radio frequency (RF) power. In vitro release of the drug-like molecule fluorescein diacetate (FDAc) from plasma-treated PLGA was tunable by controlling RF power; an increase of 65% cumulative release is reported compared to controls. Bioadhesion was sensitive to RF power and treatment time, assessed using ex vivo shear–stress tests with wetted swine aorta. We report a maximum bioadhesion ∼6-fold that of controls and 5-fold that of DOPA-based mussel adhesives tested to swine skin.1 The novelty of this post-treatment is the activation of a hydrophobic polyester film for bioadhesion, which can be quenched, while simultaneously tuning drug-release kinetics. This exemplifies the promise of plasma post-treatment for in-clinic bioadhesive activation, along with technological advancements, i.e., atmospheric plasma and hand-held “plasma pencils”.
ISSN: 1944-8244
DOI: 10.1021/am500454b
Schools: School of Materials Science & Engineering 
Rights: © 2014 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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