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Title: Addressing Unmet Clinical Needs with UV Bioadhesives
Authors: O’Rorke, Richard D.
Pokholenko, Oleksandr
Gao, Feng
Cheng, Ting
Shah, Ankur
Mogal, Vishal
Steele, Terry W. J.
Keywords: Unmet clinical applications
UV-activated bioadhesives
Issue Date: 2017
Source: O’Rorke, R. D., Pokholenko, O., Gao, F., Cheng, T., Shah, A., Mogal, V., et al. (2017). Addressing Unmet Clinical Needs with UV Bioadhesives. Biomacromolecules, 18(3), 674-682.
Series/Report no.: Biomacromolecules
Abstract: The invasive practice of suturing for wound closure has persisted for millennia; with the rate of medical development, it is staggering that there are few viable alternatives to invasive mechanical fasteners. Biocompatible and biodegradable polymers are attractive candidates for versatile bioadhesives and could revolutionize surgical procedures. Bioadhesives can be broadly placed into two groups: activated and instant. Almost all commercially available bioadhesives are instant, which cross-link by mixing two components or on contact with moisture. Activated bioadhesives, on the other hand, allow control of when and where a bioadhesive cross-links and, in some cases, the extent of cross-linking. Despite significant progress, there has been little translation of activated bioadhesives to clinical use. This review discusses recent developments in UV-activated bioadhesives toward addressing unmet clinical needs.
ISSN: 1525-7797
DOI: 10.1021/acs.biomac.6b01743
Schools: School of Materials Science & Engineering 
Rights: This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License, which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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