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Title: Raman-encoded, multivalent glycan-nanoconjugates for traceable specific binding and killing of bacteria
Authors: Hou, Shuai
Ma, Jielin
Keogh, Damien
Zhang, Jianhua
Mallick, Asadulla
Liu, Xue-Wei
Duan, Hongwei
Chan-Park, Mary B.
Mahadevegowda, Surendra Hittanahalli
Keywords: Gold Nanorods
Multivalent Glycoconjugates
Issue Date: 2018
Source: Mahadevegowda, S. H., Hou, S., Ma, J., Keogh, D., Zhang, J., Mallick, A., et al. (2018). Raman-encoded, multivalent glycan-nanoconjugates for traceable specific binding and killing of bacteria. Biomaterials Science, 6(6), 1339-1346.
Series/Report no.: Biomaterials Science
Abstract: Glycan recognition plays key roles in cell–cell and host–pathogen interactions, stimulating widespread interest in developing multivalent glycoconjugates with superior binding affinity for biological and medical uses. Here, we explore the use of Raman-encoded silver coated gold nanorods (GNRs) as scaffolds to form multivalent glycoconjugates. The plasmonic scaffolds afford high-loading of glycan density and their optical properties offer the possibilities of monitoring and quantitative analysis of glycan recognition. Using E. coli strains with tailored on/off of the FimH receptors, we have demonstrated that Raman-encoded GNRs not only allow for real-time imaging and spectroscopic detection of specific binding of the glycan–GNR conjugates with bacteria of interest, but also cause rapid eradication of the bacteria due to the efficient photothermal conversion of GNRs in the near-infrared spectral window. We envision that optically active plasmonic glycoconjugates hold great potential for screening multivalent glycan ligands for therapeutic and diagnostic applications.
ISSN: 2047-4830
DOI: 10.1039/C8BM00139A
Schools: School of Chemical and Biomedical Engineering 
School of Physical and Mathematical Sciences 
Rights: © 2018 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials Science, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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