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Title: Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
Authors: van der Plas, Mariena J. A.
Bhongir, Ravi K. V.
Kjellström, Sven
Siller, Helena
Kasetty, Gopinath
Mörgelin, Matthias
Schmidtchen, Artur
Keywords: Biological sciences
Issue Date: 2016
Source: van der Plas, M. J. A., Bhongir, R. K. V., Kjellström, S., Siller, H., Kasetty, G., Mörgelin, M., et al. (2016). Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses. Nature Communications, 7, 11567-.
Series/Report no.: Nature Communications
Abstract: Pseudomonas aeruginosa is an opportunistic pathogen known for its immune evasive abilities amongst others by degradation of a large variety of host proteins. Here we show that digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns in vitro and in vivo by preventing toll-like receptor dimerization and subsequent activation of down-stream signalling pathways. Thus, P. aeruginosa ‘hijacks’ an endogenous anti-inflammatory peptide-based mechanism, thereby enabling modulation and circumvention of host responses.
DOI: 10.1038/ncomms11567
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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