Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80676
Title: Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study
Authors: Eng, Goi Khia
Keywords: DRNTU::Social sciences::Psychology
Issue Date: 2019
Source: Eng, G. K. (2019). Clarifying the neural basis of obsessive compulsive disorder : a combined structural and functional magnetic resonance imaging study. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Obsessive-compulsive disorder (OCD) is a debilitating disorder with limited treatment efficacies. This could partly be attributed to inadequate knowledge of the neurobiological basis of the disorder. Even though OCD has a prevalence rate of 3% in Singapore, research in OCD is relatively lacking compared to other psychiatric conditions. Existing neuroimaging literature in OCD have commonly reported abnormalities within the fronto-striatal regions, and some studies also indicated the involvement of the cerebellum in the disorder. However, exact contributions of the cerebellum in OCD pathophysiology have been unexplored. This thesis aims to clarify the neural basis and examine aberrant neural activity involved in OCD pathophysiology. Four studies are presented in this thesis. Study 1 presents a meta-analysis to synthesize existing findings of differences in structural grey matter and executive-function task-related activations between OCD samples and controls. Results indicated group differences in frontal-thalamic and cerebellar grey matter, and task-related activations in the cingulate, parietal and caudate regions. These findings suggest probable involvement of regions beyond the cortico-striatal-thalamo-cortical (CSTC) circuitry in OCD pathophysiology. Findings from Study 1 set the stage for subsequent neural investigations...
URI: https://hdl.handle.net/10356/80676
http://hdl.handle.net/10220/48108
DOI: 10.32657/10220/48108
Schools: School of Social Sciences 
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SSS Theses

Files in This Item:
File Description SizeFormat 
0_Writeup_final_library.pdf11.48 MBAdobe PDFThumbnail
View/Open

Page view(s) 10

865
Updated on Jun 18, 2024

Download(s) 5

539
Updated on Jun 18, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.