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Title: Low toxicity and long circulation time of Polyampholyte-coated magnetic nanoparticles for blood pool contrast agents
Authors: Wang, Qi
Shen, Ming
Zhao, Tao
Xu, Yuanyuan
Lin, Jiang
Duan, Yourong
Gu, Hongchen
Keywords: Chemical and Biomedical Engineering
Issue Date: 2015
Source: Wang, Q., Shen, M., Zhao, T., Xu, Y., Lin, J., Duan, Y., et al. (2015). Low toxicity and long circulation time of Polyampholyte-coated magnetic nanoparticles for blood pool contrast agents. Scientific Reports, 5, 7774-.
Series/Report no.: Scientific Reports
Abstract: Polyampholyte-coated (poly(acrylic acid) (PAA)-co-3-(diethylamino)-propylamine (DEAPA)) magnetite nanoparticles (PAMNPs) have been prepared as contrasting agent used in magnetic resonance imaging (MRI). Excellent biocompatibility is required for contrasting agents used in high-resolution magnetic resonance angiography. To evaluate the biocompatibility of PAMNPs, some experiments have been conducted. The hemolysis, plasma recalcification, dynamic blood clotting, prothrombin time, inflammatory cytokine release and complement system activation assays were carried out to investigate the hemocompatibility. To evaluate the toxicity to vessel, MTT test and vascular irritation tests were conducted. Tissue toxicity test was also performed to investigate the biocompability in vivo. We also looked into the biodistribution. The results showed that PAMNPs at the working concentration (0.138 mM) present similar hemocompatibility with negative control, thus have no significant effect to vessels. PAMNPs were mainly distributed in the liver and the blood. The circulation time in blood was considerably long, with the half-time of 3.77 h in plasma. This property is advantageous for PAMNPs' use in angiography. PAMNPs could be metabolized rapidly in mice and were not observed to cause any toxic or adverse effect. In short, these results suggest that the PAMNPs have great potential to serve as safe contrast agents in magnetic resonance imaging (MRI).
ISSN: 2045-2322
DOI: 10.1038/srep07774
Schools: School of Chemical and Biomedical Engineering 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercialNoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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