Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80742
Title: Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease
Authors: Baek, Jong-Suep
Choo, Chee Chong
Qian, Cheng
Tan, Nguan Soon
Shen, Zexiang
Loo, Say Chye Joachim
Keywords: Parkinson's disease
controlled release
spray-coating
floating drug delivery system
Issue Date: 2016
Source: Baek, J.-S., Choo, C. C., Qian, C., Tan, N. S., Shen, Z., & Loo, S. C. J. (2016). Multi-drug-loaded Microcapsules with Controlled Release for Management of Parkinson's Disease. Small, 12(27), 3712-3722
Series/Report no.: Small
Abstract: Parkinson's disease (PD) is a progressive disease of the nervous system, and is currently managed through commercial tablets that do not sufficient enable controlled, sustained release capabilities. It is hypothesized that a drug delivery system that provides controlled and sustained release of PD drugs would afford better management of PD. Hollow microcapsules composed of poly-L-lactide (PLLA) and poly (caprolactone) (PCL) were prepared through a modified double-emulsion technique. They were loaded with three PD drugs, i.e. levodopa (LD), carbidopa (CD) and entacapone (ENT), at a ratio of 4:1:8, similar to commercial PD tablets. LD and CD were localized in both the hollow cavity and PLLA/PCL shell, while ENT was localized in the PLLA/PCL shell. Release kinetics of hydrophobic ENT was observed to be relatively slow as compared to the other hydrophilic drugs. It was further hypothesized that encapsulating ENT into PCL as a surface coating onto these microcapsules can aid in accelerating its release. Now, these spray-coated hollow microcapsules exhibited similar release kinetics, according to Higuchi’s rate, for all three drugs. The results suggest that multiple drug encapsulation of LD, CD and ENT in gastric floating microcapsules could be further developed for in vivo evaluation for the management of PD.
URI: https://hdl.handle.net/10356/80742
http://hdl.handle.net/10220/40745
ISSN: 1613-6810
DOI: 10.1002/smll.201600067
Rights: © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Small, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/smll.201600067].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles
SBS Journal Articles
SCELSE Journal Articles
SPMS Journal Articles

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