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Title: Understanding COPD-overlap syndromes
Authors: Poh, Tuang Yeow
Mac Aogáin, Micheál
Chan, Adrian Kwok Wai
Yii, Anthony Chau Ang
Yong, Valerie Fei Lee
Tiew, Pei Yee
Koh, Mariko Siyue
Chotirmall, Sanjay Haresh
Keywords: Chronic obstructive pulmonary disease
Overlap syndrome
Issue Date: 2017
Source: Poh, T. Y., Mac Aogáin, M., Chan, A. K. W., Yii, A. C. A., Yong, V. F. L., Tiew, P. Y., et al. (2017). Understanding COPD-overlap syndromes. Expert Review of Respiratory Medicine, 11(4), 285-298.
Series/Report no.: Expert Review of Respiratory Medicine
Abstract: Introduction: Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma. This is coined asthma-COPD overlap syndrome ('ACOS'). Other examples of such overlapping clinical states include bronchiectasis-COPD ('BCOS'), fibrosis-COPD ('FCOS') and OSA-COPD ('OCOS'). The objective of this review is to highlight similarities and differences between the COPD-overlap syndromes in terms of risk factors, pathophysiology, diagnosis and potential treatment differences. Expert commentary: As a consequence of COPD overlap syndromes, a transition from the traditional 'one size fits all' treatment approach is necessary. Greater treatment stratification according to clinical phenotype using a precision medicine approach is now required. In this light, it is important to recognize and differentiate COPD overlap syndromes as distinct disease states compared to individual diseases such as asthma, COPD, fibrosis or bronchiectasis.
ISSN: 1747-6348
DOI: 10.1080/17476348.2017.1305895
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Informa UK Ltd (trading as Taylor & Francis Group). This is the author created version of a work that has been peer reviewed and accepted for publication by Expert Review of Respiratory Medicine, Informa UK Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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