Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80784
Title: The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD
Authors: Leung, Janice M.
Tiew, Pei Yee
Mac Aogáin, Micheál
Budden, Kurtis F.
Yong, Valerie Fei Lee
Thomas, Sangeeta Susan
Pethe, Kevin
Hansbro, Philip M.
Chotirmall, Sanjay Haresh
Keywords: Acute exacerbations of chronic obstructive pulmo-nary disease
Chronic obstructive pulmonary disease
Issue Date: 2017
Source: Leung, J. M., Tiew, P. Y., Mac Aogáin, M., Budden, K. F., Yong, V. F. L., Thomas, S. S., et al. (2017). The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD. Respirology, 22(4), 634–650.
Series/Report no.: Respirology
Abstract: COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD pathogens such as Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae are strongly associated with acute exacerbations of COPD (AECOPD), the clinical relevance of these pathogens in stable COPD patients remains unclear. Immune responses in stable and colonized COPD patients are comparable to those detected in AECOPD, supporting a role for chronic colonization in COPD pathogenesis through perpetuation of deleterious immune responses. Advances in molecular diagnostics and metagenomics now allow the assessment of microbe-COPD interactions with unprecedented personalization and precision, revealing changes in microbiota associated with the COPD disease state. As microbial changes associated with AECOPD, disease severity and therapeutic intervention become apparent, a renewed focus has been placed on the microbiology of COPD and the characterization of the lung microbiome in both its acute and chronic states. Characterization of bacterial, viral and fungal microbiota as part of the lung microbiome has the potential to reveal previously unrecognized prognostic markers of COPD that predict disease outcome or infection susceptibility. Addressing such knowledge gaps will ultimately lead to a more complete understanding of the microbe-host interplay in COPD. This will permit clearer distinctions between acute and chronic infections and more granular patient stratification that will enable better management of these features and of COPD.
URI: https://hdl.handle.net/10356/80784
http://hdl.handle.net/10220/42256
ISSN: 1323-7799
DOI: 10.1111/resp.13032
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Asian Pacific Society of Respirology. This is the author created version of a work that has been peer reviewed and accepted for publication by Respirology, Asian Pacific Society of Respirology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1111/resp.13032].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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