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dc.contributor.authorLeung, Janice M.en
dc.contributor.authorTiew, Pei Yeeen
dc.contributor.authorMac Aogáin, Micheálen
dc.contributor.authorBudden, Kurtis F.en
dc.contributor.authorYong, Valerie Fei Leeen
dc.contributor.authorThomas, Sangeeta Susanen
dc.contributor.authorPethe, Kevinen
dc.contributor.authorHansbro, Philip M.en
dc.contributor.authorChotirmall, Sanjay Hareshen
dc.identifier.citationLeung, J. M., Tiew, P. Y., Mac Aogáin, M., Budden, K. F., Yong, V. F. L., Thomas, S. S., et al. (2017). The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD. Respirology, 22(4), 634–650.en
dc.description.abstractCOPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD pathogens such as Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae are strongly associated with acute exacerbations of COPD (AECOPD), the clinical relevance of these pathogens in stable COPD patients remains unclear. Immune responses in stable and colonized COPD patients are comparable to those detected in AECOPD, supporting a role for chronic colonization in COPD pathogenesis through perpetuation of deleterious immune responses. Advances in molecular diagnostics and metagenomics now allow the assessment of microbe-COPD interactions with unprecedented personalization and precision, revealing changes in microbiota associated with the COPD disease state. As microbial changes associated with AECOPD, disease severity and therapeutic intervention become apparent, a renewed focus has been placed on the microbiology of COPD and the characterization of the lung microbiome in both its acute and chronic states. Characterization of bacterial, viral and fungal microbiota as part of the lung microbiome has the potential to reveal previously unrecognized prognostic markers of COPD that predict disease outcome or infection susceptibility. Addressing such knowledge gaps will ultimately lead to a more complete understanding of the microbe-host interplay in COPD. This will permit clearer distinctions between acute and chronic infections and more granular patient stratification that will enable better management of these features and of COPD.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent67 p.en
dc.rights© 2017 Asian Pacific Society of Respirology. This is the author created version of a work that has been peer reviewed and accepted for publication by Respirology, Asian Pacific Society of Respirology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.subjectAcute exacerbations of chronic obstructive pulmo-nary diseaseen
dc.subjectChronic obstructive pulmonary diseaseen
dc.titleThe role of acute and chronic respiratory colonization and infections in the pathogenesis of COPDen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.description.versionAccepted versionen
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Appears in Collections:LKCMedicine Journal Articles

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