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Title: Microbiomes in respiratory health and disease: An Asia-Pacific perspective
Authors: Chotirmall, Sanjay Haresh
Gellatly, Shaan L.
Budden, Kurtis F.
Mac Aogáin, Micheál
Shukla, Shakti D.
Wood, David L.A.
Hugenholtz, Philip
Pethe, Kevin
Hansbro, Philip M.
Keywords: Chronic obstructive pulmonary disease
Issue Date: 2017
Source: Chotirmall, S. H., Gellatly, S. L., Budden, K. F., Mac Aogáin, M., Shukla, S. D., Wood, D. L. A., et al. (2017). Microbiomes in respiratory health and disease: An Asia-Pacific perspective. Respirology, 22(2), 240-250.
Series/Report no.: Respirology
Abstract: There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment. There are issues that are particular to the Asia-Pacific region involving diet and prevalence of specific respiratory diseases. Each of these issues is further complicated by the effects of ageing. The challenges now are to elucidate the cause and effect relationships between changes in microbiomes and respiratory diseases and how to translate these into new treatments and clinical care. Here we review the current understanding and progression in these areas.
ISSN: 1323-7799
DOI: 10.1111/resp.12971
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Asian Pacific Society of Respirology. This is the author created version of a work that has been peer reviewed and accepted for publication by Respirology, Asian Pacific Society of Respirology. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [ttp://].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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