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Title: The emergence of Aspergillus species in chronic respiratory disease
Authors: Yii, Anthony C. A.
Koh, Mariko S.
Lapperre, Therese S.
Tan, Gan L.
Chotirmall, Sanjay Haresh
Keywords: Aspergillosis
Issue Date: 2017
Source: Yii, A. C. A., Koh, M. S., Lapperre, T. S., Tan, G. L., & Chotirmall, S. H. (2017). The emergence of Aspergillus species in chronic respiratory disease. Frontiers in Bioscience, Scholar, 9, 127-138.
Series/Report no.: Frontiers in Bioscience, Scholar
Abstract: Chronic lung disease is recognized as an important risk factor for developing pulmonary aspergillosis. The development of specific aspergillus-associated syndromes depends on host immunity and underlying lung disease. In the setting of asthma, hypersensitivity to Aspergillus can lead to allergic bronchopulmonary aspergillosis (ABPA) or severe asthma with fungal sensitization (SAFS). Chronic use of systemic or inhaled corticosteroids coupled with recurrent antibiotic use for exacerbations prevalent in chronic obstructive pulmonary disease (COPD) predisposes to chronic pulmonary aspergillosis (CPA). Prior pulmonary tuberculosis is a risk factor for CPA, a syndrome with a wide range of presentations including a simple aspergilloma, chronic cavities, necrosis or fibrosis. Accumulating evidence suggests that the presence of or colonization by Aspergillus in the setting of chronic lung disease can worsen clinical course and outcomes even in the absence of overt pulmonary aspergillosis. We propose that understanding the complex interplay between host and fungi may provide key insights into the pathogenesis of Aspergillus-associated pulmonary syndromes in the setting of chronic lung disease, and provide novel therapeutic approaches to improve its identification and management.
ISSN: 1945-0516
DOI: 10.2741/S477
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2017 Frontiers in Bioscience
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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