Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80790
Title: Transforming growth factor β and severe asthma: A perfect storm
Authors: Al-Alawi, Mazen
Hassan, Tidi
Chotirmall, Sanjay Haresh
Keywords: Asthma
TGF-β
Issue Date: 2014
Source: Al-Alawi, M., Hassan, T., & Chotirmall, S. H. (2014). Transforming growth factor β and severe asthma: A perfect storm. Respiratory Medicine, 108(10), 1409-1423.
Series/Report no.: Respiratory Medicine
Abstract: Asthma is a chronic inflammatory airway disease involving complex interplay between resident and infiltrative cells, which in turn are regulated by a wide range of host mediators. Identifying useful biomarkers correlating with clinical symptoms and degree of airway obstruction remain important to effective future asthma treatments. Transforming growth factor β (TGF-β) is a major mediator involved in pro-inflammatory responses and fibrotic tissue remodeling within the asthmatic lung. Its role however, as a therapeutic target remains controversial. The aim of this review is to highlight its role in severe asthma including interactions with adaptive T-helper cells, cytokines and differentiation through regulatory T-cells. Associations between TGF-β and eosinophils will be addressed and the effects of genetic polymorphisms of the TGF-β1 gene explored in the context of asthma. We highlight TGF-β1 as a potential future therapeutic target in severe asthma including its importance in identifying emerging clinical phenotypes in asthmatic subjects who may be suitable for individualized therapy through TGF-β modulation.
URI: https://hdl.handle.net/10356/80790
http://hdl.handle.net/10220/42243
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2014.08.008
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2014 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Respiratory Medicine, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.rmed.2014.08.008].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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