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Title: N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals
Authors: Zhang, Yuexia
Du, Yu
Huang, Zhijian
Xu, Jianfeng
Wu, Xingxing
Wang, Yuhuang
Wang, Ming
Yang, Song
Webster, Richard D.
Chi, Robin Yonggui
Keywords: Chemistry and Biological Chemistry
Issue Date: 2015
Source: Zhang, Y., Du, Y., Huang, Z., Xu, J., Wu, X., Wang, Y., et al. (2015). N-Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β-Hydroxylation of Enals. Journal of the American Chemical Society, 137(7), 2416-2419.
Series/Report no.: Journal of the American Chemical Society
Abstract: An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.
ISSN: 0002-7863
DOI: 10.1021/ja511371a
Rights: © 2015 American Chemical Society (ACS).
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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