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|Title:||N‑Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β‑Hydroxylation of Enals||Authors:||Zhang, Yuexia
Webster, Richard D.
Chi, Robin Yonggui
|Keywords:||Chemistry and Biological Chemistry||Issue Date:||2015||Source:||Zhang, Y., Du, Y., Huang, Z., Xu, J., Wu, X., Wang, Y., et al. (2015). N-Heterocyclic Carbene-Catalyzed Radical Reactions for Highly Enantioselective β-Hydroxylation of Enals. Journal of the American Chemical Society, 137(7), 2416-2419.||Series/Report no.:||Journal of the American Chemical Society||Abstract:||An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations. This oxidative single-electron-transfer reaction allows for highly enantioselective access to β-hydroxyl esters that are widely found in natural products and bioactive molecules.||URI:||https://hdl.handle.net/10356/80814
|ISSN:||0002-7863||DOI:||10.1021/ja511371a||Rights:||© 2015 American Chemical Society (ACS).||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||SPMS Journal Articles|
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