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Title: Elucidating the DNA-Histone Interaction in Nucleosome from the DNA-Dendrimer Complex
Authors: Huang, Yen-Chih
Su, Chun-Jen
Chen, Chun-Yu
Chen, Hsin-Lung
Jeng, U-Ser
Berezhnoy, Nikolay V.
Nordenskiöld, Lars
Ivanov, Viktor A.
Keywords: Biological Sciences
Issue Date: 2016
Source: Huang, Y.-C., Su, C.-J., Chen, C.-Y., Chen, H.-L., Jeng, U.-S., & Berezhnoy, N. V. (2016). Elucidating the DNA-Histone Interaction in Nucleosome from the DNA-Dendrimer Complex. Macromolecules, 49 (11), 4277–4285
Series/Report no.: Macromolecules
Abstract: The electrostatic complex of DNA with poly(amidoamine) G6 dendrimer (called “dendriplex”) is used as a model system to resolve if pure electrostatic interaction can lead to the key structural features of nucleosome. Both dendrimer and histone octamer (HO) are found to attract DNA to wrap helically around them with comparable pitch lengths; however, the superhelical trajectory in the dendriplex is loose and fluctuating, whereas that in nucleosome is tight and rigid. The DNA-wrapped dendrimer particles are closely spaced along the dendriplex fiber, while the nucleosome core particles (NCPs) in the nucleosome array are separated by relatively long linker DNA. The clear contrast in structural features attests that DNA–HO interaction is beyond electrostatics, as additional specific interactions exist to fix DNA superhelical trajectory and to select the favored DNA sequence for constituting the NCP.
ISSN: 0024-9297
DOI: 10.1021/acs.macromol.6b00311
Schools: School of Biological Sciences 
Rights: © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Macromolecules, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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