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Title: Non-coding functions of alternative pre-mRNA splicing in development
Authors: Mockenhaupt, Stefan
Makeyev, Eugene V.
Keywords: Translational regulation
mRNA localization
Alternative pre-mRNA splicing
mRNA stability
Issue Date: 2015
Source: Mockenhaupt, S., & Makeyev, E. V. (2015). Non-coding functions of alternative pre-mRNA splicing in development. Seminars in Cell & Developmental Biology, 47–48, 32–39.
Series/Report no.: Seminars in cell & developmental biology
Abstract: A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2015.10.018
Schools: School of Biological Sciences 
Rights: © 2015 Published by Elsevier Ltd. Open Access funded by Biotechnology and Biological Sciences Research Council. Under a Creative Commons license
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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