Please use this identifier to cite or link to this item:
Title: Emerging functions of alternative splicing coupled with nonsense-mediated decay
Authors: Hamid, Fursham M.
Makeyev, Eugene V.
Keywords: AS-NMD
Post-transcriptional regulation of gene expression
Physiological response
RNA metabolism
Issue Date: 2014
Source: Hamid, F., & Makeyev, E. (2014). Emerging functions of alternative splicing coupled with nonsense-mediated decay. Biochemical Society Transactions, 42(4), 1168-1173.
Series/Report no.: Biochemical society transactions
Abstract: Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS–NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.
DOI: 10.1042/BST20140066
Schools: School of Biological Sciences 
Rights: © The Authors Journal compilation © 2014 Biochemical Society
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

Files in This Item:
File Description SizeFormat 
1168 full.pdf541.51 kBAdobe PDFThumbnail

Citations 10

Updated on Jun 12, 2024

Web of ScienceTM
Citations 10

Updated on Oct 28, 2023

Page view(s)

Updated on Jun 14, 2024

Download(s) 20

Updated on Jun 14, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.