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Title: MicroRNAs and their potential therapeutic applications in neural tissue engineering
Authors: Nguyen, Lan Huong
Diao, Hua Jia
Chew, Sing Yian
Keywords: RNA interference
Gene silencing
Nerve regeneration
Neural transdifferentiation
Neural differentiation
Issue Date: 2015
Source: Nguyen, L. H., Diao, H. J., & Chew, S. Y. (2015). MicroRNAs and their potential therapeutic applications in neural tissue engineering. Advanced Drug Delivery Reviews, 88, 53-66.
Series/Report no.: Advanced Drug Delivery Reviews
Abstract: The inherent poor regeneration capacity of nerve tissues, especially in the central nervous system, poses a grand challenge for neural tissue engineering. After injuries, the local microenvironment often contains potent inhibitory molecules and glial scars, which do not actively support axonal regrowth. MicroRNAs can direct fate of neural cells and are tightly controlled during nerve development. Thus, RNA interference using microRNAs is a promising method to enhance nerve regeneration. Although the physiological roles of microRNA expression levels in various cellular activities or disease conditions have been extensively investigated, the translational use of these understanding for neural tissue engineering remains limited. This review aims to highlight essential microRNAs that participate in cellular behaviors within the adult nervous system and their potential therapeutic applications. In addition, possible delivery methods are also suggested for effective gene silencing in neural tissue engineering.
ISSN: 0169-409X
DOI: 10.1016/j.addr.2015.05.007
Schools: School of Chemical and Biomedical Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2015 Elsevier B.V. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Drug Delivery Reviews, Elsevier B.V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SCBE Journal Articles

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