Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80914
Title: Synthesis and antibacterial study of sulfobetaine/quaternary ammonium-modified star-shaped poly[2-(dimethylamino)ethyl methacrylate]-based copolymers with an inorganic core
Authors: Pu, Yuji
Hou, Zheng
Khin, Mya Mya
Zamudio-Vázquez, Rubi
Poon, Kar Lai
Duan, Hongwei
Chan-Park, Mary B.
Keywords: Star Polymers
Polymethacrylate
Issue Date: 2016
Source: Pu, Y., Hou, Z., Khin, M. M., Zamudio-Vázquez, R., Poon, K. L., Duan, H., et al. (2016). Synthesis and antibacterial study of sulfobetaine/quaternary ammonium-modified star-shaped poly[2-(dimethylamino)ethyl methacrylate]-based copolymers with an inorganic core. Biomacromolecules, 18(1), 44-55.
Series/Report no.: Biomacromolecules
Abstract: Star polymers with poly[2-(dimethylamino)ethyl methacrylate] as the arms and POSS as the core (POSS-g-PDMA) were synthesized by atom transfer radical polymerization (ATRP). The effect of molecular weight on the antibacterial activity was studied and lower molecular weight POSS-g-PDMA has better bactericidal activity as measured by the minimum inhibition concentration. POSS-g-PDMA was further modified by various techniques to increase hydrophilicity in attempting to improve their antifouling activity without compromising bactericidal activity. POSS-g-PDMA was quaternized to different degrees and the antibacterial activities of the obtained quaternary polymers were studied; the antibacterial activity decreased as the degree of quaternization increased. Finally, cationic-zwitterionic polymers with both random and block structures, where PDMA and poly(sulfobetaine) were cationic and zwitterionic blocks respectively, were synthesized. The random cationic-zwitterionic polymers showed poor antibacterial activity while the block polymers retained the antibacterial activity of the pristine POSS-g-PDMA. The block copolymers of POSS-g-(PDMA-b-polysulfobetaine) showed enhanced antifouling property and serum stability as seen by their nanoparticle size stability in the presence of serum and reduced red blood cell aggregation. The antibacterial kinetics showed that E. coli can be killed within 30 min by both random and block polymers. Finally, block polymers showed low toxicity to zebrafish embryo and could be potentially used in aquaculture antibacterial applications.
URI: https://hdl.handle.net/10356/80914
http://hdl.handle.net/10220/45025
ISSN: 1525-7797
DOI: 10.1021/acs.biomac.6b01279
Rights: © 2016 American Chemical Society (ACS). This is the author created version of a work that has been peer reviewed and accepted for publication by Biomacromolecules, American Chemical Society (ACS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biomac.6b01279].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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