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Title: Lipid-coated polymeric nanoparticles for cancer drug delivery
Authors: Krishnamurthy, Sangeetha
Vaiyapuri, Rajendran
Zhang, Liangfang
Chan, Juliana Maria Shuping
Keywords: Liposomes
Issue Date: 2015
Source: Krishnamurthy, S., Vaiyapuri, R., Zhang, L., & Chan, J. M. (2015). Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomaterials Science, 3(7), 923-936.
Series/Report no.: Biomaterials Science
Abstract: Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.
ISSN: 2047-4830
DOI: 10.1039/C4BM00427B
Rights: © 2015 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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