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Title: Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years
Authors: Ludwig, Ulla
Holzner, Daniela
Denzer, Christian
Greinert, Artur
Haenle, Mark Martin
Oeztuerk, Suemeyra
Koenig, Wolfgang
Boehm, Bernhard Otto
Mason, Richard Andrew
Kratzer, Wolfgang
Graeter, Tilmann
Keywords: Hypothyroidism
Cross-sectional studies
Issue Date: 2015
Source: Ludwig, U., Holzner, D., Denzer, C., Greinert, A., Haenle, M. M., Oeztuerk, S., et al (2015). Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years. BMC Endocrine Disorders, 15, 41-.
Series/Report no.: BMC Endocrine Disorders
Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis. Methods: Data from 2,445 subjects (51.7 % females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression. Results: The prevalence of hepatic steatosis in the study collective was 27.4 % (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p = 0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = <.0001). Conclusions: The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis.
ISSN: 1472-6823
DOI: 10.1186/s12902-015-0030-5
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Lee Kong Chian School of Medicine
Rights: © 2015 Ludwig et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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