Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMundargi, Raghavendraen
dc.contributor.authorVenkataraman, Divyaen
dc.contributor.authorKumar, Saranyaen
dc.contributor.authorMogal, Vishalen
dc.contributor.authorOrtiz, Raphaelen
dc.contributor.authorSteele, Terry W. J.en
dc.contributor.authorLoo, Joachim Say Chyeen
dc.contributor.authorVenkatraman, Subbu S.en
dc.identifier.citationMundargi, R., Venkataraman, D., Kumar, S., Mogal, V., Ortiz, R., Loo, J. S. C., et al (2015). Novel Sensor-Enabled Ex Vivo Bioreactor: A New Approach towards Physiological Parameters and Porcine Artery Viability. BioMed Research International, 2015, 958170-.en
dc.description.abstractThe aim of the present work is to design and construct an ex vivo bioreactor system to assess the real time viability of vascular tissue. Porcine carotid artery as a model tissue was used in the ex vivo bioreactor setup to monitor its viability under physiological conditions such as oxygen, pressure, temperature, and flow. The real time tissue viability was evaluated by monitoring tissue metabolism through a fluorescent indicator “resorufin.” Our ex vivo bioreactor allows real time monitoring of tissue responses along with physiological conditions. These ex vivo parameters were vital in determining the tissue viability in sensor-enabled bioreactor and our initial investigations suggest that, porcine tissue viability is considerably affected by high shear forces and low oxygen levels. Histological evaluations with hematoxylin and eosin and Masson’s trichrome staining show intact endothelium with fresh porcine tissue whereas tissues after incubation in ex vivo bioreactor studies indicate denuded endothelium supporting the viability results from real time measurements. Hence, this novel viability sensor-enabled ex vivo bioreactor acts as model to mimic in vivo system and record vascular responses to biopharmaceutical molecules and biomedical devices.en
dc.format.extent8 p.en
dc.relation.ispartofseriesBioMed Research Internationalen
dc.rights© 2015 Raghavendra Mundargi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleNovel Sensor-Enabled Ex Vivo Bioreactor: A New Approach towards Physiological Parameters and Porcine Artery Viabilityen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
Appears in Collections:MSE Journal Articles

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.