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Title: Thermoreversible gelation of hydroxypropylmethylcellulose in simulated body fluids
Authors: Joshi, Sunil Chandrakant
Lam, Yee Cheong
Tam, K. C.
Liu, Shao Qiong
Keywords: Hydroxypropylmethylcellulose
Simulated body fluids
Sol–gel transition
Differential scanning calorimetry
Issue Date: 2007
Source: Liu, S. Q., Joshi, S. C., Lam, Y. C., & Tam, K. C. (2007). Thermoreversible gelation of hydroxypropylmethylcellulose in simulated body fluids. Carbohydrate Polymers, 72(1), 133-143.
Series/Report no.: Carbohydrate Polymers
Abstract: The thermoreversible gelation of hydroxypropylmethylcellulose (HPMC) in simulated intestinal/gastric fluids (SIF/SGF) was monitored by microcalorimetry (micro-DSC), turbidity and rheometry. Both SGF and SIF facilitated sol–gel transition in HPMC without changing the patterns of gelation behavior. The sol–gel transition was found to be an entropy driven and temperature dependent process. Solution isotopic effects using Deuteraed water (D2O) yielded a linear decrease in the temperature of endothermic maximum (Tmax) with the increase in the molar ratio of D2O, indicating that polymer–polymer direct hydrogen bonding (interchain hydrogen bonding) was involved in the gelation process in addition to hydrophobic association. It was found that the Tmax shifted roughly linear to lower temperature with the increase of SGF/SIF content. This effect can be interpreted by the salting-out effect. Three distinct regions of the enthalpy and entropy changes (ΔH and ΔS) depending on buffer content were observed. However, ΔH and ΔS were linear with HPMC weight concentration. The aqueous solutions of HPMC showed a low critical solution temperature (LCST) and form an elastic gel with increasing temperature. Rheological measurements indicated that the sol–gel transition proceeded in two stages. The gel elasticity was affected by the polymer concentration and buffer content. The results obtained from different techniques are consistent and show similar trends.
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2007.07.040
Schools: School of Chemical and Biomedical Engineering 
School of Mechanical and Aerospace Engineering 
Rights: © 2007 Elsevier Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Carbohydrate Polymers, Elsevier Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
SCBE Journal Articles

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