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Title: Coffee consumption and NAFLD: a community based study on 1223 subjects
Authors: Graeter, Tilmann
Niedermayer, Pia C.
Mason, Richard A.
Oeztuerk, Suemeyra
Haenle, Mark M.
Koenig, Wolfgang
Boehm, Bernhard Otto
Kratzer, Wolfgang
Keywords: Caffeine
Hepatic steatosis
Fatty liver
Alanine aminotransferase
Population-based cross-sectional study
Issue Date: 2015
Source: Graeter, T., Niedermayer, P. C., Mason, R. A., Oeztuerk, S., Haenle, M. M., Koenig, W., et al. (2015). Coffee consumption and NAFLD: a community based study on 1223 subjects. BMC Research Notes, 8, 640-.
Series/Report no.: BMC Research Notes
Abstract: Background: Objective of the present cross-sectional study was to investigate the impact of caffeine consumption on fatty liver and serum alanine aminotransferase (ALT) concentrations in a random population sample. Methods: All subjects (n = 1452; 789 women, 663 men; average age 42.3 ± 12.8 years) underwent ultrasonographic examination of the liver and completed a standardized questionnaire regarding personal and lifestyle data, in particular relating to coffee consumption and past medical history. In addition, anthropometric data were documented and laboratory examinations performed. Statistical interpretation of the data was performed descriptively and by means of bivariate and multivariate analysis. Results: Data of the present study demonstrated a significant association between hepatic steatosis male gender (p < 0.0001), advanced age (p < 0.0001) and elevated body-mass index (BMI; p < 0.0001). No association between caffeine consumption and fatty liver was identified. An association between caffeine consumption and elevated serum ALT concentrations was not identified. Conclusions: The findings of the present study provide no evidence for an association between caffeine consumption and either the prevalence of hepatic steatosis or serum ALT concentrations.
ISSN: 1756-0500
DOI: 10.1186/s13104-015-1645-3
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2015 Graeter et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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