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Title: An excitatory GABA loop operating in vivo
Authors: Astorga, Guadalupe
Bao, Jin
Marty, Alain
Augustine, George James
Franconville, Romain
Jalil, Abdelali
Bradley, Jonathan
Llano, Isabel
Keywords: GABA
Parallel fibers
Issue Date: 2015
Source: Astorga, G., Bao, J., Marty, A., Augustine, G. J., Franconville, R., Jalil, A., et al. (2015). An excitatory GABA loop operating in vivo. Frontiers in Cellular Neuroscience, 9, 275-.
Series/Report no.: Frontiers in Cellular Neuroscience
Abstract: While it has been proposed that the conventional inhibitory neurotransmitter GABA can be excitatory in the mammalian brain, much remains to be learned concerning the circumstances and the cellular mechanisms governing potential excitatory GABA action. Using a combination of optogenetics and two-photon calcium imaging in vivo, we find that activation of chloride-permeable GABAA receptors in parallel fibers (PFs) of the cerebellar molecular layer of adult mice causes parallel fiber excitation. Stimulation of PFs at submaximal stimulus intensities leads to GABA release from molecular layer interneurons (MLIs), thus creating a positive feedback loop that enhances excitation near the center of an activated PF bundle. Our results imply that elevated chloride concentration can occur in specific intracellular compartments of mature mammalian neurons and suggest an excitatory role for GABAA receptors in the cerebellar cortex of adult mice.
ISSN: 1662-5102
DOI: 10.3389/fncel.2015.00275
Rights: © 2015 Astorga, Bao, Marty, Augustine, Franconville, Jalil, Bradley and Llano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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