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Title: Construction of a high-density linkage map and fine mapping of QTL for growth in Asian seabass
Authors: Wang, Le
Wan, Zi Yi
Bai, Bin
Huang, Shu Qing
Chua, Elaine
Lee, May
Pang, Hong Yan
Wen, Yan Fei
Liu, Peng
Liu, Feng
Sun, Fei
Lin, Grace
Ye, Bao Qing
Yue, Gen Hua
Issue Date: 2015
Source: Wang, L., Wan, Z. Y., Bai, B., Huang, S. Q., Chua, E., Lee, M., et al. (2015). Construction of a high-density linkage map and fine mapping of QTL for growth in Asian seabass. Scientific Reports, 5, 16358-.
Series/Report no.: Scientific Reports
Abstract: A high-density genetic map is essential for comparative genomic studies and fine mapping of QTL, and can also facilitate genome sequence assembly. Here, a high density genetic map of Asian seabass was constructed with 3321 SNPs generated by sequencing 144 individuals in a F2 family. The length of the map was 1577.67 cM with an average marker interval of 0.52 cM. A high level of genomic synteny among Asian seabass, European seabass, Nile tilapia and stickleback was detected. Using this map, one genome-wide significant and five suggestive QTL for growth traits were detected in six linkage groups (i.e. LG4, LG5, LG11, LG13, LG14 and LG15). These QTL explained 10.5–16.0% of phenotypic variance. A candidate gene, ACOX1 within the significant QTL on LG5 was identified. The gene was differentially expressed between fast- and slow-growing Asian seabass. The high-density SNP-based map provides an important tool for fine mapping QTL in molecular breeding and comparative genome analysis.
ISSN: 2045-2322
DOI: 10.1038/srep16358
Schools: School of Biological Sciences 
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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