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Title: TiO2-nanoparticles shield HPEKs against ZnO-induced genotoxicity
Authors: Kathawala, Mustafa Hussain
Yun, Zhao
Chu, Justin Jang Hann
Ng, Kee Woei
Loo, Say Chye Joachim
Keywords: DNA damage
Dual nanoparticle
Oxidative stress
Titanium oxide
Zinc oxide
Issue Date: 2015
Source: Kathawala, M. H., Yun, Z., Chu, J. J. H., Ng, K. W., & Loo, S. C. J. (2015). TiO2-nanoparticles shield HPEKs against ZnO-induced genotoxicity. Materials & Design, 88, 41-50.
Series/Report no.: Materials and Design
Abstract: Usage of sunscreens has become commonplace amongst outdoor sports. Recently, nanomaterials have gained increasing market share as ingredients in sunscreens (as well as other topically applied products). In particular ZnO and TiO2 nanoparticles (ZNP and TNP) have found their niche in this application. This study investigated the safety aspects of these nanoparticles from a combinatorial exposure point of view. Focus was on investigating generation of oxidative stress and induction of DNA damage which the two nanoparticles caused. It was found that TNPs triggered stronger oxidative stress than ZNPs but ZNPs remained more potent at causing DNA damage. The individual mechanisms of DNA damage were found to be through oxidative stress for TNPs (indirect genotoxicity) and through Zn2 + ion nuclear uptake resulting in DNA damage for ZNP (direct genotoxicity). Interesting, it was found that intracellular TNPs could adsorb Zn2 + ions and lower their nuclear uptake in turn shielding the HPEKs from ZNP-induced genotoxicity. Toxicological assessments of dual nanoparticle systems remain an unstudied area and based on the results obtained deserves further consideration.
ISSN: 0261-3069
DOI: 10.1039/c3cc48810a10.1016/j.matdes.2015.08.108
Schools: School of Materials Science & Engineering 
Research Centres: Singapore Centre for Environmental Life Sciences Engineering 
Rights: © 2015 Elsevier Ltd.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles
SCELSE Journal Articles

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