Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81256
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dc.contributor.authorZhang, Fengyingen
dc.contributor.authorNgoc, Nguyen Thi Quynhen
dc.contributor.authorTay, Bao Huien
dc.contributor.authorMendyk, Aleksanderen
dc.contributor.authorShao, Yu-Hsuanen
dc.contributor.authorLau, Raymonden
dc.date.accessioned2016-06-20T05:55:47Zen
dc.date.accessioned2019-12-06T14:26:40Z-
dc.date.available2016-06-20T05:55:47Zen
dc.date.available2019-12-06T14:26:40Z-
dc.date.issued2014en
dc.identifier.citationZhang, F., Ngoc, N. T. Q., Tay, B. H., Mendyk, A., Shao, Y. H., & Lau, R. (2015). Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery. Molecular Pharmaceutics, 12(1), 223-231.en
dc.identifier.issn1543-8384en
dc.identifier.urihttps://hdl.handle.net/10356/81256-
dc.description.abstractNovel roughness-controlled mannitol/LB Agar microparticles were synthesized by polymorphic transformation and self-assembly method using hexane as the polymorphic transformation reagent and spray-dried mannitol/LB Agar microparticles as the starting material. As-prepared microparticles were characterized by Fourier transform infrared spectra (FTIR), X-ray diffraction spectra (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), and Andersen Cascade Impactor (ACI). The XRD and DSC results indicate that after immersing spray-dried mannitol/LB Agar microparticles in hexane, β-mannitol was completely transformed to α-mannitol in 1 h, and all the δ-mannitol was transformed to α form after 14 days. SEM shows that during the transformation the nanobelts on the spray-dried mannitol/LB Agar microparticles become more dispersed and the contour of the individual nanobelts becomes more noticeable. Afterward, the nanobelts self-assemble to nanorods and result in rod-covered mannitol/LB Agar microparticles. FTIR indicates new hydrogen bonds were formed among mannitol, LB Agar, and hexane. SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. Transformed microparticles show higher FPFs than commercially available lactose carriers. An FPF of 28.6 ± 2.4% was achieved by microparticles transformed from spray-dried microparticles using 2% mannitol(w/v)/LB Agar as feed solution. It is comparable to the highest FPF reported in the literature using lactose and spray-dried mannitol as carriers.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent31 p.en
dc.language.isoenen
dc.relation.ispartofseriesMolecular Pharmaceuticsen
dc.rights© 2014 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Molecular Pharmaceutics, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/mp5005614].en
dc.subjectimage analysisen
dc.subjectself-assemblyen
dc.subjectpulmonary deliveryen
dc.subjectpolymorphic transformationen
dc.subjectsurface morphologyen
dc.subjectmannitolen
dc.titleRoughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Deliveryen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.identifier.doi10.1021/mp5005614en
dc.description.versionAccepted versionen
item.fulltextNo Fulltext-
item.grantfulltextnone-
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