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Title: Efficient DNA-Mediated Electron Transport in Ionic Liquids
Authors: Xuan, Shuguang
Meng, Zhenyu
Wu, Xiangyang
Wong, Jiun-Ru
Devi, Gitali
Yeow, Edwin Kok Lee
Shao, Fangwei
Keywords: Conductive biomolecule
Issue Date: 2016
Source: Xuan, S., Meng, Z., Wu, X., Wong, J.-R., Devi, G., Yeow, E. K. L., et al. (2016). Efficient DNA-Mediated Electron Transport in Ionic Liquids. ACS Sustainable Chemistry & Engineering, 4(12), 6703-6711.
Series/Report no.: ACS Sustainable Chemistry & Engineering
Abstract: Electron conductivity of duplex DNA has promising applications in fabricating DNA based biosensors and electronic devices for biomimic solar cells. However, in aqueous solution DNA-mediated electron transfer (ET) is often far from ideal for these applications. We reported here that in hydrated ionic liquids (IL) electron can propagate through 4 nm of duplex DNA, and higher ET efficiency was achieved over longer distance which yielded a noncanonical negative distance decay parameter (γ = −0.02 Å–1). Fluorescence studies and ET efficiency of duplex DNA in IL-D2O revealed that the binding of both cationic and anionic species of hydrated IL in DNA minor groove and the exclusion of water from the DNA hydration layer significantly improved base-pair stacking of duplex DNA to achieve efficient electric conductivity. As an oxidation reaction of nucleic acids, efficient DNA ET observed here suggested that IL could be a promising nonorganic and nonaqueous solvent for redox reactions of biomacromolecules.
DOI: 10.1021/acssuschemeng.6b01605
Schools: School of Physical and Mathematical Sciences 
Rights: © 2016 American Chemical Society (ACS). This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Sustainable Chemistry & Engineering, American Chemical Society (ACS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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