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Title: Pulsed laser diode based optoacoustic imaging of biological tissues
Authors: Upputuri, Paul Kumar
Pramanik, Manojit
Keywords: Optoacoustic tomography
Pulsed laser diode
Deep tissue imaging
Biological imaging
Issue Date: 2015
Source: Upputuri, P. K., & Pramanik, M. (2015). Pulsed laser diode based optoacoustic imaging of biological tissues. Biomedical Physics & Engineering Express, 1(4), 045010-.
Series/Report no.: Biomedical Physics & Engineering Express
Abstract: Optoacoustic tomography (OAT) is a promising hybrid imaging modality for many biomedical applications. However, the use of Nd:YAG laser as excitation source makes the OAT system expensive, and non-portable. Miniaturization of OAT system is an immediate task to make it a potential tool for both preclinical and clinical studies. In this work, we present an OA system that uses a miniaturized pulsed laser diode which can provide near infrared pulses at ~803 nm. With laser fluence ~0.3 mJ cm−2 on the tissue surface, we achieved 3 cm deep imaging in chicken tissue. The high pulse repetition rate of the diode laser allowed rapid acquisition of OA cross-sectional images with good image quality. The results promise that the proposed system has potential to be used as an alternative to Nd:YAG based OAT systems for biological imaging applications.
ISSN: 2057-1976
DOI: 10.1088/2057-1976/1/4/045010
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2015 IOP Publishing Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomedical Physics & Engineering Express, IOP Publishing Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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