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Title: Long-lived innate IL-17–producing γ/δ T cells modulate antimicrobial epithelial host defense in the colon
Authors: Abdul Rashid Mohammad Muzaki
Soncin, Irene
Setiagani, Yolanda Aphrilia
Sheng, Jianpeng
Tetlak, Piotr
Karjalainen, Klaus
Ruedl, Christiane
Keywords: T Cells
DRNTU::Science::Biological sciences
Issue Date: 2017
Source: Abdul Rashid Mohammad Muzaki., Soncin, I., Setiagani, Y. A., Sheng, J., Tetlak, P., Karjalainen, K.,& Ruedl, C. (2017). Long-Lived Innate IL-17–Producing γ/δ T Cells Modulate Antimicrobial Epithelial Host Defense in the Colon. The Journal of Immunology, 199(10), 3691-3699. doi:10.4049/jimmunol.1701053
Series/Report no.: The Journal of Immunology
Abstract: Intestinal IL-17–producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17–producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β. In the absence of γ/δ T cells or after IL-17 neutralization, this epithelial response was dramatically reduced, underlining the protective role of this unique subpopulation of innate γ/δ T17 cells in the colonic mucosa.
ISSN: 0022-1767
DOI: 10.4049/jimmunol.1701053
Schools: School of Biological Sciences 
Rights: © 2017 The American Association of Immunologists, Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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