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Title: Fluorospectroscopy of Dye-Loaded Liposomes in Photonic Crystal Fibers
Authors: Yong, Derrick
Lee, Elizabeth
Yu, Xia
Chan, Chi Chiu
Keywords: Fluorescence
Light emitting diodes
Photonic crystal fibers
Surface treatment
Issue Date: 2016
Source: Yong, D., Lee, E., Yu, X., & Chan, C. C. (2016). Fluorospectroscopy of Dye-Loaded Liposomes in Photonic Crystal Fibers. IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 1-6.
Series/Report no.: IEEE Journal of Selected Topics in Quantum Electronics
Abstract: The immobilization and probing of liposomes within photonic crystal fibers was demonstrated for the first time. A bioactive surface was used to tether the liposomes. This bioactive surface consisted of streptavidin bound to a photochemically functionalized biotin layer. Bound streptavidin, hence, enabled the further binding of biotinylated dye-loaded liposomes. In-fiber fluorescence spectroscopy was used to quantify the streptavidin coverage density. The same method was also used to characterize the surface-tethered liposomes. The further observation of a unique phenomenon-photobleaching dequenching-was used for the first time as an indication of liposomal content retention. This indicated no rupturing of liposomes, highlighting them as bioderived analogues to dye-doped nanoparticles. The demonstrated integration of liposomes with optical waveguides shows potential as a biointegrated photonic device.
ISSN: 1077-260X
DOI: 10.1109/JSTQE.2015.2479919
Schools: School of Chemical and Biomedical Engineering 
Organisations: A*STAR SIMTech
Rights: © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles
SIMTech Journal Articles

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