Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81508
Title: Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial
Authors: Lee, Bonsan Bonne
Toh, Swee-Ling
Ryan, Suzanne
Simpson, Judy M.
Clezy, Kate
Bossa, Laetitia
Rice, Scott A.
Marial, Obaydullah
Weber, Gerard
Kaur, Jasbeer
Boswell-Ruys, Claire
Goodall, Stephen
Middleton, James
Tudehope, Mark
Kotsiou, George
Keywords: Urinary prophylaxis
Microbial community profiles
Multi-resistant organisms
Antibiotic resistance
Probiotics
Biofilm
Issue Date: 2016
Source: Lee, B. B., Toh, S. L., Ryan, S., Simpson, J. M., Clezy, K., Bossa, L., et al. (2016). Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a study protocol for a randomised controlled trial. BMC Urology, 16, 18-.
Series/Report no.: BMC Urology
Abstract: Background: Urinary tract infections [UTIs] are very common in people with Spinal Cord Injury [SCI]. UTIs are increasingly difficult and expensive to treat as the organisms that cause them become more antibiotic resistant. Among the SCI population, there is a high rate of multi-resistant organism [MRO] colonisation. Non-antibiotic prevention strategies are needed to prevent UTI without increasing resistance. Probiotics have been reported to be beneficial in preventing UTIs in post-menopausal women in several in vivo and in vitro studies. The main aim of this study is to determine whether probiotic therapy with combinations of Lactobacillus reuteri RC-14 + Lactobacillus rhamnosus GR-1 [RC14-GR1] and/or Lactobacillus rhamnosus GG + Bifidobacterium BB-12 [LGG-BB12] are effective in preventing UTI in people with SCI compared to placebo.
URI: https://hdl.handle.net/10356/81508
http://hdl.handle.net/10220/40803
ISSN: 1471-2490
DOI: 10.1186/s12894-016-0136-8
Schools: School of Biological Sciences 
Rights: © 2016 Lee et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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