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Title: Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing
Authors: Cai, Elijah Zhengyang
Teo, Erin Yiling
Jing, Lim
Koh, Yun Pei
Qian, Tan Si
Wen, Feng
Lee, James Wai Kit
Hing, Eileen Chor Hoong
Yap, Yan Lin
Lee, Hanjing
Lee, Chuen Neng
Teoh, Swee-Hin
Lim, Jane
Lim, Thiam Chye
Keywords: Wounds
Hyaluronic acid
Issue Date: 2014
Source: Cai, E. Z., Teo, E. Y., Jing, L., Koh, Y. P., Qian, T. S., Wen, F., et al. (2014). Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing. Archives of Plastic Surgery, 41(6), 638-646.
Series/Report no.: Archives of Plastic Surgery
Abstract: Background: The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions: BPM is comparable to Mepitel as a safe and efficacious wound dressing.
ISSN: 2234-6163
DOI: 10.5999/aps.2014.41.6.638
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2014 The Korean Society of Plastic and Reconstructive Surgeons. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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