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dc.contributor.authorCai, Elijah Zhengyangen
dc.contributor.authorTeo, Erin Yilingen
dc.contributor.authorJing, Limen
dc.contributor.authorKoh, Yun Peien
dc.contributor.authorQian, Tan Sien
dc.contributor.authorWen, Fengen
dc.contributor.authorLee, James Wai Kiten
dc.contributor.authorHing, Eileen Chor Hoongen
dc.contributor.authorYap, Yan Linen
dc.contributor.authorLee, Hanjingen
dc.contributor.authorLee, Chuen Nengen
dc.contributor.authorTeoh, Swee-Hinen
dc.contributor.authorLim, Janeen
dc.contributor.authorLim, Thiam Chyeen
dc.identifier.citationCai, E. Z., Teo, E. Y., Jing, L., Koh, Y. P., Qian, T. S., Wen, F., et al. (2014). Bio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressing. Archives of Plastic Surgery, 41(6), 638-646.en
dc.description.abstractBackground: The combination of polycaprolactone and hyaluronic acid creates an ideal environment for wound healing. Hyaluronic acid maintains a moist wound environment and accelerates the in-growth of granulation tissue. Polycaprolactone has excellent mechanical strength, limits inflammation and is biocompatible. This study evaluates the safety and efficacy of bio-conjugated polycaprolactone membranes (BPM) as a wound dressing. Methods: 16 New Zealand white rabbits were sedated and local anaesthesia was administered. Two 3.0×3.0 cm full-thickness wounds were created on the dorsum of each rabbit, between the lowest rib and the pelvic bone. The wounds were dressed with either BPM (n=12) or Mepitel (n=12) (control), a polyamide-silicon wound dressing. These were evaluated macroscopically on the 7th, 14th, 21st, and 28th postoperative days for granulation, re-epithelialization, infection, and wound size, and histologically for epidermal and dermal regeneration. Results: Both groups showed a comparable extent of granulation and re-epithelialization. No signs of infection were observed. There was no significant difference (P>0.05) in wound size between the two groups. BPM (n=6): 8.33 cm2, 4.90 cm2, 3.12 cm2, 1.84 cm2; Mepitel (n=6): 10.29 cm2, 5.53 cm2, 3.63 cm2, 2.02 cm2; at the 7th, 14th, 21st, and 28th postoperative days. The extents of epidermal and dermal regeneration were comparable between the two groups. Conclusions: BPM is comparable to Mepitel as a safe and efficacious wound dressing.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent9 p.en
dc.relation.ispartofseriesArchives of Plastic Surgeryen
dc.rights© 2014 The Korean Society of Plastic and Reconstructive Surgeons. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectHyaluronic aciden
dc.titleBio-Conjugated Polycaprolactone Membranes: A Novel Wound Dressingen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.description.versionPublished versionen
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