Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81645
Title: Principles of electrostatic interactions and self-assembly in lipid/peptide/DNA systems: Applications to gene delivery
Authors: Berezhnoy, Nikolay V.
Korolev, Nikolay
Nordenskiöld, Lars
Keywords: Chromatin
DNA condensation
Issue Date: 2013
Source: Berezhnoy, N. V., Korolev, N., & Nordenskiöld, L. (2014). Principles of electrostatic interactions and self-assembly in lipid/peptide/DNA systems: Applications to gene delivery. Advances in Colloid and Interface Science, 205, 221-229.
Series/Report no.: Advances in Colloid and Interface Science
Abstract: Recently, great progress has been achieved in development of a wide variety of formulations for gene delivery in vitro and in vivo, which include lipids, peptides and DNA (LPD). Additionally, application of natural histone–DNA complexes (chromatin) in combination with transfection lipids has been suggested as a potential route for gene delivery (chromofection). However, the thermodynamic mechanisms responsible for formation of the ternary lipid–peptide–DNA supramolecular structures have rarely been analyzed. Using recent experimental studies on LPD complexes (including mixtures of chromatin with cationic lipids) and general polyelectrolyte theory, we review and analyze the major determinants defining the internal structure, particle composition and size, surface charge and ultimately, transfection properties of the LPD formulations.
URI: https://hdl.handle.net/10356/81645
http://hdl.handle.net/10220/40870
ISSN: 0001-8686
DOI: 10.1016/j.cis.2013.08.008
Rights: © 2013 Elsevier.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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