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Title: Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering
Authors: Jayaraman, Praveena
Gandhimathi, Chinnasamy
Venugopal, Jayarama Reddy
Becker, David Laurence
Ramakrishna, Seeram
Srinivasan, Dinesh Kumar
Keywords: Electrospray; nanoparticles; drug delivery systems; bone tissue; regenerative medicine
Issue Date: 2015
Source: Jayaraman, P., Gandhimathi, C., Venugopal, J. R., Becker, D. L., Ramakrishna, S., & Srinivasan, D. K. (2015). Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering. Advanced Drug Delivery Reviews, 94, 77-95.
Series/Report no.: Advanced Drug Delivery Reviews
Abstract: Generating porous topographic substrates, by mimicking the native extracellular matrix (ECM) to promote the regeneration of damaged bone tissues, is a challenging process. Generally, scaffolds developed for bone tissue regeneration support bone cell growth and induce bone-forming cells by natural proteins and growth factors. Limitations are often associated with these approaches such as improper scaffold stability, and insufficient cell adhesion, proliferation, differentiation, and mineralization with less growth factor expression. Therefore, the use of engineered nanoparticles has been rapidly increasing in bone tissue engineering (BTE) applications. The electrospray technique is advantageous over other conventional methods as it generates nanomaterials of particle sizes in the micro/nanoscale range. The size and charge of the particles are controlled by regulating the polymer solution flow rate and electric voltage. The unique properties of nanoparticles such as large surface area-to-volume ratio, small size, and higher reactivity make them promising candidates in the field of biomedical engineering. These nanomaterials are extensively used as therapeutic agents and for drug delivery, mimicking ECM, and restoring and improving the functions of damaged organs. The controlled and sustained release of encapsulated drugs, proteins, vaccines, growth factors, cells, and nucleotides from nanoparticles has been well developed in nanomedicine. This review provides an insight into the preparation of nanoparticles by electrospraying technique and illustrates the use of nanoparticles in drug delivery for promoting bone tissue regeneration.
ISSN: 0169-409X
DOI: 10.1016/j.addr.2015.09.007
Rights: © 2015 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Drug Delivery Reviews, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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