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Title: Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study
Authors: Gao, Fei
Ong, Yi Hong
Li, Gaoming
Feng, Xiaohua
Liu, Quan
Zheng, Yuanjin
Keywords: Raman spectroscopy
Issue Date: 2015
Source: Gao, F., Ong, Y. H., Li, G., Feng, X., Liu, Q., & Zheng, Y. (2015). Fast photoacoustic-guided depth-resolved Raman spectroscopy: a feasibility study. Optics Letters, 40(15), 3568-3571.
Series/Report no.: Optics Letters
Abstract: In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of faster operation speed due to photoacoustic time-of-flight measurement and guidance, compared with the conventional depth-resolved Raman spectroscopy method. In addition, further combination with advanced optical-focusing techniques in biological-scattering medium could potentially enable the proposed approach for cancer diagnostics with both tight and fast optical focusing at the desired depth of tumor.
ISSN: 0146-9592
DOI: 10.1364/OL.40.003568
Schools: School of Chemical and Biomedical Engineering 
School of Electrical and Electronic Engineering 
Rights: © 2015 Optical Society of America. This paper was published in Optics Letters and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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