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Title: SAW sensor for Influenza A virus detection enabled with efficient surface functionalization
Authors: Jiang, Ying
Tan, Chin Yaw
Tan, Sze Yu
Wong, Miki Shi Fei
Chen, Yi Fan
Zhang, Lei
Yao, Kui
Gan, Samuel Ken En
Verma, Chandra
Tan, Yee-Joo
Keywords: SAW
Issue Date: 2014
Source: Jiang, Y., Tan, C. Y., Tan, S. Y., Wong, M. S. F., Chen, Y. F., Zhang, L., et al. (2015). SAW sensor for Influenza A virus detection enabled with efficient surface functionalization. Sensors and Actuators B: Chemical, 209, 78-84.
Series/Report no.: Sensors and Actuators B: Chemical
Abstract: Surface acoustic wave (SAW) sensors using Love wave were designed and fabricated with SiO2-coated piezoelectric LiNbO3 wafers for Influenza A viral antigen detection, in which the targeted analyte was selectively captured at the surface through the antigen and antibody interaction enabled with appropriate surface functionalization. It was found that triethoxysilylbutylaldehyde (ALTES) and triethoxysilylundecanal ethylene glycol acetal (ACTES) are effective chemical reagents for immobilizing Influenza A hemagglutinin (HA) antibodies on the SiO2/LiNbO3 SAW surface. The detection limit of Influenza A HA H1N1 antigen at an analyte concentration as low as 1 ng mL−1 was demonstrated without any compensation design at room temperature with our obtained SAW sensors with the HA antibodies immobilized at ALTES-functionalized surface.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2014.11.103
Rights: © 2014 Elsevier.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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