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Title: The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity
Authors: Lu, Xinyi
Sachs, Friedrich
Ramsay, LeeAnn
Jacques, Pierre-Étienne
Göke, Jonathan
Bourque, Guillaume
Ng, Huck-Hui
Keywords: Long non-coding RNAs
Pluripotent stem cells
Issue Date: 2014
Source: Lu, X., Sachs, F., Ramsay, L., Jacques, P.-É., Göke, J., Bourque, G., et al. (2014). The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature Structural & Molecular Biology, 21(4), 423-425.
Series/Report no.: Nature Structural & Molecular Biology
Abstract: Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.
ISSN: 1545-9993
DOI: 10.1038/nsmb.2799
Schools: School of Biological Sciences 
Rights: © 2014 Nature America.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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