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Title: The role of SON in splicing, development, and disease
Authors: Lu, Xinyi
Ng, Huck-Hui
Bubulya, Paula A.
Keywords: RNA
Issue Date: 2014
Source: Lu, X., Ng, H.-H., & Bubulya, P. A. (2014). The role of SON in splicing, development, and disease. Wiley Interdisciplinary Reviews: RNA, 5(5), 637-646.
Series/Report no.: Wiley Interdisciplinary Reviews: RNA
Abstract: SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in maintaining cellular health were unveiled. Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis. Here we review the progress that has been made in studying this multifunctional protein and discuss questions that remain to be answered about SON.
ISSN: 1757-7004
DOI: 10.1002/wrna.1235
Schools: School of Biological Sciences 
Rights: © 2014 John Wiley & Sons, Ltd.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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