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Title: Butelase-mediated synthesis of protein thioesters and its application for tandem chemoenzymatic ligation
Authors: Cao, Yuan
Nguyen, Kien Truc Giang
Tam, James P.
Liu, Chuan-Fa
Keywords: catalytic efficiency
Issue Date: 2015
Source: Cao, Y., Nguyen, G. K. T., Tam, J. P., & Liu, C.-F. (2015). Butelase-mediated synthesis of protein thioesters and its application for tandem chemoenzymatic ligation. Chem. Commun., 51(97), 17289-17292.
Series/Report no.: Chemical Communications
Abstract: Using a recently discovered peptide ligase, butelase 1, we developed a novel method to access protein thioesters in good yield. We successfully combined it with native chemical ligation and sortase-mediated ligation in tandem for protein C-terminal labeling and dual-terminal labeling to exploit the orthogonality of these three ligation methods.
ISSN: 1359-7345
DOI: 10.1039/C5CC07227A
Schools: School of Biological Sciences 
Rights: © 2015 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Chemical Communications, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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