Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81839
Title: Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes
Authors: Than, Aung
He, Hui Ling
Chua, Si Hui
Xu, Dan
Sun, Lei
Leow, Melvin Khee-Shing
Chen, Peng
Keywords: Adipocyte
Adipose tissue
Browning
Uncoupling protein 1
Metabolic Diseases
Apelin
Issue Date: 2015
Source: Than, A., He, H. L., Chua, S. H., Xu, D., Sun, L., Leow, M. K.-S., et al. (2015). Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes. Journal of Biological Chemistry, 290(23), 14679-.
Series/Report no.: Journal of Biological Chemistry
Abstract: Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism. Here, we report that apelin-APJ signalling promotes brown adipocyte differentiation, by increasing the expressions of brown adipogenic and thermogenic transcriptional factors via PI3kinase/Akt and AMPK signalling pathways. It is also found that apelin relieves the TNFα inhibition on brown adipogenesis. In addition, apelin increases the basal activity of brown adipocytes, as evidenced by the increased PGC1α and UCP1 expressions, mitochondrial biogenesis, and oxygen consumption. Finally, we provide both in vitro and in vivo evidence that apelin is able to increase the brown-like characteristics in white adipocytes. This study, for the first time, reveals the brown adipogenic and browning effects of apelin, and suggests a potential therapeutic route to combat obesity and related metabolic disorders.
URI: https://hdl.handle.net/10356/81839
http://hdl.handle.net/10220/39721
ISSN: 0021-9258
DOI: 10.1074/jbc.M115.643817
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2015 American Society for Biochemistry and Molecular Biology (ASBMB). This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology (ASBMB). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1074/jbc.M115.643817].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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