Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81850
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dc.contributor.authorLu, Shengtaoen
dc.contributor.authorLiu, Fangen
dc.contributor.authorXing, Bengangen
dc.contributor.authorYeow, Edwin Kok Leeen
dc.date.accessioned2016-01-13T07:51:36Zen
dc.date.accessioned2019-12-06T14:41:32Z-
dc.date.available2016-01-13T07:51:36Zen
dc.date.available2019-12-06T14:41:32Z-
dc.date.issued2015en
dc.identifier.citationLu, S., Liu, F., Xing, B., & Yeow, E. K. L. (2015). Nontoxic colloidal particles impede antibiotic resistance of swarming bacteria by disrupting collective motion and speed. Physical Review E, 92, 062706-.en
dc.identifier.issn1539-3755en
dc.identifier.urihttps://hdl.handle.net/10356/81850-
dc.description.abstractA monolayer of swarming B. subtilis on semisolid agar is shown to display enhanced resistance against antibacterial drugs due to their collective behavior and motility. The dynamics of swarming motion, visualized in real time using time-lapse microscopy, prevents the bacteria from prolonged exposure to lethal drug concentrations. The elevated drug resistance is significantly reduced when the collective motion of bacteria is judiciously disrupted using nontoxic polystyrene colloidal particles immobilized on the agar surface. The colloidal particles block and hinder the motion of the cells, and force large swarming rafts to break up into smaller packs in order to maneuver across narrow spaces between densely packed particles. In this manner, cohesive rafts rapidly lose their collectivity, speed, and group dynamics, and the cells become vulnerable to the drugs. The antibiotic resistance capability of swarming B. subtilis is experimentally observed to be negatively correlated with the number density of colloidal particles on the engineered surface. This relationship is further tested using an improved self-propelled particle model that takes into account interparticle alignment and hard-core repulsion. This work has pertinent implications on the design of optimal methods to treat drug resistant bacteria commonly found in swarming colonies.en
dc.format.extent10 p.en
dc.language.isoenen
dc.relation.ispartofseriesPhysical Review Een
dc.rights© 2015 American Physical Society. This paper was published in Physical Review E and is made available as an electronic reprint (preprint) with permission of American Physical Society. The published version is available at: [http://dx.doi.org/10.1103/PhysRevE.92.062706]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.en
dc.subjectSelf-propelled particlesen
dc.subjectColloidsen
dc.titleNontoxic colloidal particles impede antibiotic resistance of swarming bacteria by disrupting collective motion and speeden
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.identifier.doi10.1103/PhysRevE.92.062706en
dc.description.versionPublished versionen
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