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Title: Regulatory networks of non-coding RNAs in brown/beige adipogenesis
Authors: Xu, Shaohai
Chen, Peng
Sun, Lei
Keywords: Brown/beige adipocyte
Issue Date: 2015
Source: Xu, S., Chen, P., & Sun, L. (2015). Regulatory networks of non-coding RNAs in brown/beige adipogenesis. Bioscience Reports, 35(5), e00262-.
Series/Report no.: Bioscience Reports
Abstract: BAT (brown adipose tissue) is specialized to burn fatty acids for heat generation and energy expenditure to defend against cold and obesity. Accumulating studies have demonstrated that manipulation of BAT activity through various strategies can regulate metabolic homoeostasis and lead to a healthy phenotype. Two classes of ncRNA (non-coding RNA), miRNA and lncRNA (long non-coding RNA), play crucial roles in gene regulation during tissue development and remodelling. In the present review, we summarize recent findings on regulatory role of distinct ncRNAs in brown/beige adipocytes, and discuss how these ncRNA regulatory networks contribute to brown/beige fat development, differentiation and function. We suggest that targeting ncRNAs could be an attractive approach to enhance BAT activity for protecting the body against obesity and its pathological consequences.
ISSN: 0144-8463
DOI: 10.1042/BSR20150155
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2015 Authors. This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution Licence 3.0.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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