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Title: Palladacycle Promoted Base Controlled Regio- and Enantioselective Hydrophosphination of 2-Pyridylacrylate/amide and the Cytotoxicity of their Gold Complexes
Authors: Jia, Yu-Xiang
Chew, Renta Jonathan
Li, Bin-Bin
Zhu, Pengcheng
Li, Yongxin
Pullarkat, Sumod Appukuttan
Tan, Nguan Soon
Leung, Pak-Hing
Keywords: Palladium compounds
antineoplastic agent
Issue Date: 2015
Source: Jia, Y.-X., Chew, R. J., Li, B.-B., Zhu, P., Li, Y., Pullarkat, S. A., et al. (2015). Palladacycle promoted base controlled regio- and enantioselective hydrophosphination of 2-pyridylacrylate/amide and the cytotoxicity of their gold complexes. Dalton Transactions, 44(40), 17557-17564.
Series/Report no.: Dalton Transactions
Abstract: The regioselective asymmetric hydrophosphination of pyridine-functionalized alkenes can be achieved in the presence of stoichiometric amounts of the chiral palladium complex (R)-1. The presence or absence of base affords the respective β- and α-adducts with excellent regiocontrol. Chiral gold-phosphine complexes incorporating the adducts exhibited good in vitro anticancer activity against the breast cancer cell line MDA-MB-231. Selectivity between the cancer cell line and normal cells was also observed.
ISSN: 1477-9226
DOI: 10.1039/C5DT02694F
Schools: School of Biological Sciences 
School of Physical and Mathematical Sciences 
Rights: © 2015 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Dalton Transactions, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
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