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Title: Graphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitors
Authors: Li, Nan
Wang, Xuewan
Chen, Jie
Sun, Lei
Chen, Peng
Keywords: 2D Materials
Fluorometric sensor
Issue Date: 2015
Source: Li, N., Wang, X., Chen, J., Sun, L., & Chen, P. (2015). Graphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitors. 2D Materials, 2(3), 034018-.
Series/Report no.: 2D Materials
Abstract: Graphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide spectrum of novel applications including development of optical sensors. Herein, a GQD-based fluorometric sensor is devised to detect acetylcholinesterase (AChE, a critical enzyme in central nervous system and neuromuscular junctions) with an ultralow detection limit (0.58 pM with S/N of 5.0), using a photoluminescence 'turn-off' mechanism. This simple 'mix-and-detect' platform can also be employed to sense a variety of compounds that can directly or indirectly inhibit the enzymatic activities of AChE, such as nerve gases, pesticides, and therapeutic drugs. As the proof-of-concept demonstrations, we show the sensitive detection of paraoxon (a pesticide), tacrine (a drug to treat Alzheimer's disease), and dopamine (an important neurotransmitter).
ISSN: 2053-1583
DOI: 10.1088/2053-1583/2/3/034018
Rights: © 2015 IOP Publishing Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by 2D Materials, IOP Publishing Ltd. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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