Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/81905
Title: Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles
Authors: Lio, Daniel
Yeo, David
Xu, Chenjie
Keywords: Drug delivery
Core-shell structure
Alginate-PLGA microparticles
Issue Date: 2016
Source: Lio, D., Yeo, D., & Xu, C. (2016). Control of Alginate Core Size in Alginate-Poly (Lactic-Co-Glycolic) Acid Microparticles. Nanoscale Research Letters, 11(1), 9-.
Series/Report no.: Nanoscale Research Letters
Abstract: Core-shell alginate-poly (lactic-co-glycolic) acid (PLGA) microparticles are potential candidates to improve hydrophilic drug loading while facilitating controlled release. This report studies the influence of the alginate core size on the drug release profile of alginate-PLGA microparticles and its size. Microparticles are synthesized through double-emulsion fabrication via a concurrent ionotropic gelation and solvent extraction. The size of alginate core ranges from approximately 10, 50, to 100 μm when the emulsification method at the first step is homogenization, vortexing, or magnetic stirring, respectively. The second step emulsification for all three conditions is performed with magnetic stirring. Interestingly, although the alginate core has different sizes, alginate-PLGA microparticle diameter does not change. However, drug release profiles are dramatically different for microparticles comprising different-sized alginate cores. Specifically, taking calcein as a model drug, microparticles containing the smallest alginate core (10 μm) show the slowest release over a period of 26 days with burst release less than 1 %.
URI: https://hdl.handle.net/10356/81905
http://hdl.handle.net/10220/39715
ISSN: 1931-7573
DOI: 10.1186/s11671-015-1222-7
Rights: © 2016 Lio et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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